Study comparing mitochondria in males and females finds extreme differences
A study led by Suzanne Edmands at USC Dornsife found sex-specific gene activity in mitochondria of copepods, with implications for human health. Tailoring treatments based on sex differences could improve efficacy.
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A study led by Suzanne Edmands, a professor of biological sciences at USC Dornsife, has revealed significant differences in gene activity within mitochondria between males and females. While the research focused on copepods, the findings have implications for human medicine due to similarities in mitochondrial genomes. Dysfunctional mitochondria are linked to various diseases like muscular dystrophy and Alzheimer's. The study suggests that current treatments, which are the same for both sexes, may need to be tailored to each sex for better efficacy. The research showed that males exhibit more activity in protein-coding mitochondrial genes, while females have higher expression in genes related to producing and maintaining mitochondria. Understanding these sex-specific differences can guide the development of sex-specific mitochondrial therapies, including mitochondrial replacement therapy. The study highlights the importance of considering sex-specific mitochondrial effects in disease treatment and may influence future research in this area.
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