July 16th, 2024

Who's got the guts to go to the moon?

The article critiques modern "moonshot" initiatives in fields like cancer research for lacking groundbreaking results despite substantial funding. It advocates for supporting unconventional ideas to drive genuine scientific innovation.

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Who's got the guts to go to the moon?

The article questions the effectiveness of modern scientific endeavors labeled as "moonshots" in areas like cancer research. Despite significant funding, initiatives like the NIH Cancer Moonshot are criticized for not achieving groundbreaking results. The piece argues that many projects funded as "high-risk" are actually conventional research efforts, lacking true innovation. It highlights the importance of taking reputational risks in funding unconventional ideas that may lead to significant breakthroughs, using historical examples like the discovery of iodine's role in preventing goiters. The author suggests that true scientific progress requires supporting unconventional thinkers who challenge established norms, even if it means facing ridicule or skepticism. The article concludes by emphasizing the need for funding entities to prioritize genuine innovation over maintaining the status quo, encouraging the pursuit of bold and unconventional ideas in scientific research.

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Link Icon 5 comments
By @gus_massa - 9 months
> Maybe curing cancer in the 2020s is way harder than going to the moon in the 1960s. I have no idea. But it doesn’t sound like we’re even trying to cure cancer.

Yep, that's the problem. After 1969, a moonshot means two things:

1) It's hard, very hard.

2) It's possible in a short time frame.

Curing cancer is hard. Check.

It's not possible in a short time frame. They are just lying. They call it a moonshot to sound cool.

Curing cancer in 10 years is like promising to open a hotel in all planets and all major moons in the solar system. And curing cancer is perhaps harder.

On the other hand there have been a lot of small improvements. I know someone that got like 10 years on no cancer grow with https://en.wikipedia.org/wiki/Hormonal_therapy_(oncology) . It's not a cure, but 10 more years is a good step.

By @gregw2 - 9 months
The author doesn’t explain why their “give someone 200k for life” funding idea works but tenure doesn’t.

Also no reference to if/whether/why DARPA had a good funding model or not.

By @ngcc_hk - 9 months
Very strange to say "nobody has gone to the moon." Not only a few did the real thing, the idea that those moonshot does not reach their target depends upon the wrong idea that there is, say, one cancer and one cancer cure. As we cannot hence we are not there. But we did a lot and some move so much that a lot of patients are saved. And like we all know now about the mRNA but that is not given as an example, but why?

Strange article. Just argue for clickbait or what?

By @Apocryphon - 9 months
I get what the article is trying to argue for, but using cancer moonshots as his example of what is wrong feels is far less convincing in light of him admitting that he has no idea of how oncology works.
By @muixoozie - 9 months
Am I the only one that immediately nopes out of articles that have popups / subscribe. The article has to really be on a topic I care about to take the time to x those out.