July 18th, 2024

60-year-old German man likely seventh person to be effectively cured from HIV

A 60-year-old German man is potentially the seventh person cured of HIV through a stem cell transplant. The procedure, not widely applicable, shows promise for HIV cure research without complete gene elimination.

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60-year-old German man likely seventh person to be effectively cured from HIV

A 60-year-old German man is likely the seventh person to be effectively cured of HIV after receiving a stem cell transplant, as announced by doctors. This procedure, which is only suitable for individuals with both HIV and aggressive leukemia, is not widely applicable to the nearly 40 million people worldwide living with HIV. The patient, referred to as the "next Berlin patient," underwent a bone marrow transplant in 2015 and ceased taking anti-retroviral drugs in late 2018. Medical researchers report that almost six years later, he shows no signs of HIV or cancer. While not confirmed, the case is highly suggestive of an HIV cure, according to Christian Gaebler, a doctor-researcher involved in the treatment. This development is seen as promising for the search for an HIV cure that could benefit a larger pool of patients, as it demonstrates that complete elimination of the CCR5 gene may not be necessary for successful gene therapy.

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By @jfengel - 9 months
Too bad it's so drastic. There's also a huge problem with autoimmune disorders, and it would be great to reboot them. Unfortunately you basically have to be near dead from leukemia before this procedure is reasonable.
By @nilsbunger - 9 months
I wonder if they can evolve this into an autologous stem cell transplant: take a patient's own bone marrow sample, do the genetic mutation, and insert it back? It avoids the graft-versus-host issues of using stem cells from another person, so it should be reasonably safe (though still a major procedure)
By @init2null - 9 months
A 10% risk of death of a massive gamble compared to the alternatives. I can only hope this leads to a more useful solution than immune system replacement. I expect many would prefer a life of daily medication, or even shots every few months, which looks to be a promising form of treatment.
By @ImHereToVote - 9 months
Is there are reason bone marrow has to be inside bones. Couldn't you graft a bone marrow organ next to the liver or something?
By @KennyBlanken - 9 months
Imagine how farther along we'd be on HIV treatment if we hadn't had someone in the White House who decided HIV was a 'gay people disease' and just shrugged.

Every time I hear someone praise Reagan all I can think about is how sat on his hands and did nothing while a hundred thousand Americans died - 30,000 in the last year of his presidency alone - because of bigotry on the part of him and the Christian Right, who are still to this day screaming that LGBTQ people shouldn't have the same rights as everyone else.