New biomaterial regrows damaged cartilage in joints

Northwestern University researchers have developed a new bioactive material that effectively regenerates damaged cartilage in knee joints, as demonstrated in a large-animal model. This innovative material, which resembles a rubbery substance, consists of a complex network designed to mimic the natural environment of cartilage. In a study published in the Proceedings of the National Academy of Sciences, the material was applied to cartilage defects in sheep, leading to significant repair within six months. The regenerated cartilage contained essential biopolymers, such as collagen II and proteoglycans, which are crucial for joint resilience and pain-free movement. The researchers believe this biomaterial could potentially replace the need for knee replacement surgeries and treat degenerative conditions like osteoarthritis. The material combines a bioactive peptide that promotes cartilage growth with modified hyaluronic acid, a natural component found in joints. The study's lead researcher, Samuel I. Stupp, emphasized the importance of this advancement in addressing the lack of natural cartilage regeneration in adults. Future applications may include using this material during surgical procedures to enhance cartilage repair, offering a more durable solution compared to current methods that often result in inferior fibrocartilage.

- Northwestern University has developed a biomaterial that regenerates damaged cartilage in knee joints.

- The material showed significant cartilage repair in sheep models within six months.

- It combines a bioactive peptide and modified hyaluronic acid to mimic natural cartilage.

- The research could lead to alternatives for knee replacement surgeries and treatments for osteoarthritis.

- The study highlights the potential for improved long-term joint health and mobility.