Alternate RNA decoding results in stable and abundant proteins in mammals
A study on bioRxiv reveals that alternate RNA decoding enhances protein stability and abundance in mammals, identifying 60,024 amino acid substitutions across various tissues and cancers, with implications for disease mechanisms.
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A recent study published on bioRxiv investigates the impact of alternate RNA decoding on protein stability and abundance in mammals. Researchers analyzed extensive proteomic and transcriptomic data from over 1,000 human samples, encompassing six cancer types and 26 healthy tissues. The analysis revealed 60,024 high-confidence amino acid substitutions across 1,990 proteins, with some substitutions being tissue-specific or associated with particular cancers. Notably, proteins resulting from alternate translation were found to be more abundant than their canonical counterparts in many cases, indicating a phenomenon of sense codon recoding. The study identified various protein types affected, including transcription factors and signaling proteins, and explored factors influencing substitution abundance, such as protein stability and RNA modifications. The findings suggest that alternate translation plays a significant role in diversifying mammalian proteomes and is linked to tissue-specific protein expression and disease mechanisms. The research highlights the conservation of these processes between humans and mice, emphasizing the importance of alternate translation in understanding protein function and stability in mammals.
- Alternate RNA decoding leads to the production of stable and abundant proteins in mammals.
- The study analyzed data from over 1,000 human samples, identifying 60,024 amino acid substitutions.
- Proteins from alternate translation were often more abundant than their canonical versions.
- The research indicates a link between alternate translation and tissue-specific proteomes and diseases.
- Findings suggest conservation of alternate translation mechanisms between humans and mice.
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