September 9th, 2024

Newly Discovered Antibody Protects Against All Covid-19 Variants

Researchers at The University of Texas at Austin discovered the SC27 antibody, which neutralizes all SARS-CoV-2 variants, highlighting hybrid immunity's benefits and potential for universal vaccine development.

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Newly Discovered Antibody Protects Against All Covid-19 Variants

Researchers at The University of Texas at Austin have identified a new antibody, SC27, that can neutralize all known variants of SARS-CoV-2, the virus responsible for COVID-19, as well as related coronaviruses. This discovery was part of a study on hybrid immunity, which combines the effects of infection and vaccination. The research team utilized advanced technology, including single-cell DNA sequencing and proteomics, to isolate and characterize the antibody from a single patient. SC27 effectively binds to the spike protein of the virus, preventing it from infecting cells. The findings suggest that hybrid immunity offers enhanced protection compared to either infection or vaccination alone. The research team has filed a patent for SC27, which could lead to large-scale production for future treatments. This work is particularly relevant as COVID-19 continues to evolve, highlighting the ongoing need for innovative solutions to combat the virus. The study was published in Cell Reports Medicine and involved collaboration with multiple institutions, receiving funding from the National Institutes of Health and the Bill & Melinda Gates Foundation.

- A newly discovered antibody, SC27, neutralizes all known COVID-19 variants.

- The research emphasizes the benefits of hybrid immunity from both infection and vaccination.

- SC27 could lead to the development of a universal vaccine against rapidly mutating viruses.

- The study utilized advanced technologies for antibody isolation and characterization.

- The research team has filed a patent application for SC27.

Link Icon 5 comments
By @arcastroe - 7 months
> The University of Texas at Austin discovered and isolated a broadly neutralizing plasma antibody, called SC27, from a single patient.

> The researchers have filed a patent application for SC27.

The antibody itself is patentable? What about the patient whose body created the antibody? Does this patient have any rights to it?

There's something about this that I don't like. Sure, if the antibody was engineered by the researchers, I could see it being patented. But discovered and taken as-is from another patient and then patented seems like a gray area to me.

By @scohesc - 7 months
I would hope the individual that produced the antibody is well rewarded for what their body did.

Unless this antibody is somehow similar across all antibodies created as a reaction to an infection - that single patient should get a part of the profits from all vaccines/treatments derived from the antibody made in their body - it's only fair if their "work" is part of making vaccines that are then sold to others globally on a wide scale.

Then again, this is the medical industrial complex, so I'm sure they'll find a way to justify not reimbursing the patient. Unless I'm mistaken?

By @westurner - 7 months
> The technology used to isolate the antibody, termed Ig-Seq, gives researchers a closer look at the antibody response to infection and vaccination using a combination of single-cell DNA sequencing and proteomics.

/? ig-seq [ site:github.com ] : https://www.google.com/search?q=ig-seq+site%3Agithub.com

https://www.illumina.com/science/sequencing-method-explorer/... :

> Rep-Seq is a collective term for repertoire sequencing technologies. DNA sequencing of immunoglobulin genes (Ig-seq) and molecular amplification fingerprinting

> [ Ig-seq] is a targeted gDNA amplification method performed with primers complementary to the rearranged V-region gene (VDJ recombinant). Amplification of cDNA is then performed with the appropriate 5’ primers.

By @howard941 - 7 months
What's the path for taking this discovery into a vaccine?
By @486sx33 - 7 months
This is super exciting!