Adderall in Higher Doses May Raise Psychosis Risk, Study Says

A recent study published in The American Journal of Psychiatry indicates that higher doses of ADHD stimulant medications, specifically Adderall and Vyvanse, may significantly increase the risk of developing psychosis or mania. The research found that individuals taking high doses—defined as over 40 mg of Adderall or 100 mg of Vyvanse—had a fivefold increased risk of experiencing these severe side effects compared to those not on stimulants. Medium doses also posed a risk, with a 3.5 times higher likelihood of psychosis or mania. The study analyzed health records of patients aged 16 to 35 who were hospitalized for their first psychiatric episodes between 2005 and 2019. Notably, the risk was not observed in patients using methylphenidate-based medications like Ritalin. The findings suggest that dosage is a critical factor, and individuals with a family history of psychosis or those using non-prescribed stimulants may be at greater risk. Experts emphasize the need for careful monitoring of patients on higher doses of amphetamines and further research to understand the underlying risk factors. The study highlights the importance of awareness regarding the potential psychiatric side effects of stimulant medications, especially as prescriptions have surged in recent years.

- Higher doses of Adderall and Vyvanse may increase psychosis risk significantly.

- The study found a fivefold increased risk for high doses compared to non-users.

- Medium doses also present a notable risk, with a 3.5 times higher likelihood of psychosis.

- No increased risk was found for patients using methylphenidate medications.

- Further research is needed to identify risk factors and monitor patients effectively.