October 5th, 2024

The brain has its own microbiome

Recent research indicates the human brain has its own microbiome, influencing neurodegenerative disorders. Infections may contribute to cognitive decline, with antibiotics showing potential in alleviating symptoms and guiding future treatments.

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The brain has its own microbiome

Recent research has revealed that the human brain hosts its own microbiome, consisting of various microbes, including bacteria, viruses, and fungi. This discovery has significant implications for understanding neurodegenerative disorders such as Alzheimer's disease. A notable case is that of Nikki Schultek, who experienced a range of debilitating symptoms, including chronic pain and cognitive decline, which were eventually linked to infections. After receiving antibiotic treatment for these infections, her symptoms, including brain fog and memory issues, went into remission. This case has spurred interest in the potential role of infections in cognitive decline and the brain's microbial community. Researchers are now exploring how this microbiome could contribute to preventing neurodegenerative diseases and possibly reversing symptoms when they occur. The growing understanding of the brain's microbiome opens new avenues for treatment and prevention strategies in neurology.

- The human brain contains its own microbiome, which may influence health.

- Infections have been linked to cognitive decline, as seen in individual cases.

- Antibiotic treatment has shown potential in alleviating symptoms of neurodegeneration.

- Research is expanding on the role of the brain's microbial community in neurodegenerative diseases.

- Understanding the brain microbiome could lead to new treatment and prevention methods.

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By @codethief - 3 months
I mentioned Adam Savage's "Scariest [Podcast] Episode Yet" in a different context the other day[0] in which I remember Joe DeRisi[1] saying something along the lines of brain & spinal fluid being "absolutely pristine" when it comes to the presence/absence of a microbiome (in healthy individuals) and that it'd be real problem if there were one.

I'm just a layman but can anyone ELI5 how this can be squared with the OP, specifically with statements like

> It turns out our grey matter is teeming with bacteria, viruses and fungi

[0]: https://news.ycombinator.com/item?id=41752034

[1]: https://en.m.wikipedia.org/wiki/Joseph_DeRisi

By @FollowingTheDao - 3 months
I have a genetic partial immunodeficiency (PNP Deficiency) and I constantly get fungal infections. Living in warm, humid climates is a challenge for me.

Reading just the beginning of that article "she experienced chronic pain, digestive problems and a cardiac arrhythmia", well, that is my life. I constantly have minor aspergillosis, and I have some lung nodules from some past fungal infections as well.

Keeping the microbiome under control is all about a healthy immune system.

But since my disorder affected my mental state they just labeled me as a psychiatric case and did not look any further, If anyone here is a doctor, please do not give up on psychiatric patients. Thanks.

Interesting case here:

Aspergillosis of the central nervous system in a previously healthy patient that simulated Creutzfeldt–Jakob disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180434/

"He was admitted to the hospital with an occipital headache which he had endured for 2 months. For over 1 and a half months, he had also experienced behavioral disorders and a disruption of higher mental functions. He had retrograde and anterograde amnesia with both echolalia and the presence of visual hallucinations. "

By @jac241 - 3 months
If there’s a brain microbiome then why does nothing grow when I send CSF from an EVD?
By @uLogMicheal - 3 months
Next will we find that there is an exchange of microbes between the brain and gut?
By @MailleQuiMaille - 3 months
Surprised as how such basic stuff gets "discovered" now and then. For all the toot of science, how come it took us that long to realise such a basic (in appearance at least I'm sure) fact ?
By @gytisgreitai - 3 months
Full article anyone?
By @hajjf - 3 months
Where are we in the hype cycle regarding microbiome? Would it be feasible to launch a startup that leverages the synergy between AI, the blockchain and gut bacteria? I am serious!