A simplified form of life: Scientists build modules for a synthetic cell
Scientists at the University of Groningen are creating simplified synthetic cells to understand life formation, collaborating with six institutes to simplify energy conversion and integrate it with cell division processes.
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Scientists at the University of Groningen are working on creating simplified synthetic cells, aiming to understand how lifeless molecules can form living cells. Led by Professor Bert Poolman, the research focuses on building artificial versions of biological systems that can serve as components for synthetic cells. Poolman has published two papers detailing systems for energy conversion and nutrient processing in synthetic cells. The research involves a collaboration of six Dutch institutes under the BaSyc project, which seeks to develop the necessary elements for synthetic cells. Poolman's team has simplified the energy conversion process, replicating the function of mitochondria using only five components instead of the hundreds typically required. This system allows for the production of ATP, the energy currency of cells, using arginine as the sole energy source. Additionally, they have created a vesicle that generates an electrical potential to transport nutrients, demonstrating the feasibility of expanding the system to include metabolic processes. The next phase of the research will integrate these energy-producing systems with a synthetic cell division system. The ongoing EVOLF project aims to explore how various lifeless modules can combine to create living cells, potentially providing a blueprint for life and enhancing our understanding of biological processes.
- Researchers are developing simplified synthetic cells to understand the formation of life.
- The project involves collaboration among six Dutch research institutes.
- Energy conversion in synthetic cells has been simplified to just five components.
- The research aims to integrate energy production with synthetic cell division.
- The findings could lead to a better understanding of life and its applications.
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