January 23rd, 2025

Bacteria in Polymers Form Cables That Grow into Living Gels

Scientists from Caltech and Princeton discovered that E. coli bacteria form cable-like structures in polymer solutions, which may help understand cystic fibrosis and biofilm management in medical and industrial contexts.

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Bacteria in Polymers Form Cables That Grow into Living Gels

Scientists from Caltech and Princeton University have discovered that bacterial cells can form long, cable-like structures when grown in polymer solutions, such as mucus. This phenomenon, described in a paper published in Science Advances, could have significant implications for understanding diseases like cystic fibrosis, where mucus concentration increases and can lead to severe bacterial infections. The research focused on E. coli bacteria, which, when placed in a polymeric environment, remained attached after division, creating intertwined structures that resemble living gels. The study revealed that the growth of these cables is influenced by external pressure from the surrounding polymers, a concept known as depletion interaction. The findings suggest that this cable formation may serve a dual purpose: either helping bacteria evade immune responses by becoming larger or potentially making them easier to expel from the body. The research opens new avenues for exploring the biological implications of these structures and their role in biofilms, which pose challenges in medical and industrial contexts. The study was supported by various scientific organizations and involved collaboration with researchers from MIT and Princeton.

- Bacteria can form cable-like structures in polymer solutions, resembling living gels.

- This discovery may aid in understanding cystic fibrosis and bacterial infections.

- The growth of these structures is influenced by external pressure from surrounding polymers.

- The research has implications for biofilm management in medical and industrial settings.

- Further studies are needed to explore the biological significance of cable formation.

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By @asimpletune - 3 months
It’s fascinating that this could either be beneficial to bacteria, by forming larger bodies and making it more difficult to be attacked by immune systems, or detrimental, by clumping up and then being cleaned up by hairs within the body, such as the lungs. I imagine the answer is both, depending on the context.
By @daneel_w - 3 months
I make kombucha* at home and observe something similar whenever I start a new batch using a small piece of culture taken from an old container. Either the yeast or the bacteria - or both in symbiosis - form the typical stringy structures seen in so many petri dishes, that radiate from the "mother" outwards to the edges of the container. As time passes, each area isolated between the crossing strings slowly thickens on the surface and eventually merge with the rest of the growth as a single colony.

* https://en.wikipedia.org/wiki/Kombucha