High-fat diet, microbiome-gut-brain axis signaling, and anxiety in rats
Researchers studied male rats on a high-fat diet (HFD) to analyze its impact on gut microbiome, brain gene expression, and anxiety behavior. HFD led to reduced microbiome diversity, altered gene expression, and increased anxiety-like behaviors.
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Researchers conducted a study on male rats to investigate the effects of a high-fat diet (HFD) on the gut microbiome, brain serotonergic gene expression, and anxiety-related behavior. The study found that rats on a HFD showed decreased gut microbiome diversity, altered community composition, and increased expression of serotonergic genes in the brainstem, particularly in regions associated with stress and anxiety responses. These changes were linked to increased anxiety-like defensive behaviors in the rats. The HFD also affected the ratio of Firmicutes/Bacteroidetes and the abundance of specific bacterial taxa. The study suggests that HFD-induced obesity alters microbiome-gut-serotonergic brain axis signaling, leading to heightened anxiety-related responses in rats. The research aimed to fill gaps in understanding how HFD influences gut microbiome diversity, brain gene expression, and anxiety-related behaviors in male Wistar rats. The study involved a 9-week HFD protocol, behavioral tests, and brain tissue analysis to explore these relationships.
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