Effects of psychedelics on neurogenesis and brain plasticity A systematic review
A systematic review examines psychedelics' impact on neurogenesis and brain plasticity, suggesting their potential in treating mood disorders. The study analyzed 205 articles, categorizing findings on various compounds' effects. It includes both experimental and human studies, aiming to inform new therapeutic approaches for neuropsychiatric conditions.
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The systematic review explores the effects of psychedelics on neurogenesis and brain plasticity. It highlights the continuous generation of new neurons in the mammalian brain, known as adult neurogenesis, and its potential link to mood disorders. Psychedelic compounds have shown promise as therapeutic options for neuropsychiatric disorders, with reports suggesting they can increase adult neurogenesis. The review analyzed 205 articles, with 68 meeting the criteria for further review. The findings were categorized into CB1 agonists, NMDA antagonists, harmala alkaloids, tryptamines, and entactogens, detailing their impact on neurogenesis and brain plasticity. The study encompassed both experimental models and human studies, aiming to provide insights into how psychedelics influence the birth of new neurons and other brain processes. The research may contribute to the development of novel therapeutic strategies for neuropsychiatric disorders. The authors disclosed no competing interests, and the preprint is available under a CC-BY-ND 4.0 International license.
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