July 2nd, 2024

Creatine improves physical function and body composition in older adults

A systematic review and meta-analysis evaluated creatine supplementation's impact on physical function in at-risk individuals. Results from 33 trials indicated improvements in muscle strength and performance, emphasizing the need for further high-quality research.

Read original articleLink Icon
Creatine improves physical function and body composition in older adults

The systematic review and meta-analysis on creatine supplementation for optimizing physical function in individuals at risk of functional disability aimed to assess the efficacy of creatine replacement through supplementation. The study included randomized controlled trials comparing creatine supplementation with placebos in older adults and adults with chronic diseases. Results from 33 trials involving 1076 participants showed that creatine supplementation improved sit-to-stand performance, upper-body muscle strength, handgrip strength, and lean tissue mass. The quality of evidence for these outcomes was deemed low or very low due to a high risk of bias. The study highlighted the need for high-quality prospective randomized controlled trials to confirm the observed benefits of creatine supplementation on physical function. The findings suggest a potential benefit of creatine supplementation in improving muscle function and physical performance in individuals at risk of functional disability.

Related

A 5,2 Intermittent Fasting Meal Replacement Diet for Adults with Diabetes

A 5,2 Intermittent Fasting Meal Replacement Diet for Adults with Diabetes

A randomized trial compared 5:2 intermittent fasting with metformin and empagliflozin in diabetic adults. Results showed improved glycemic control with reduced HbA1c levels and fasting glucose, suggesting potential benefits for diabetes management.

The ketogenic diet improves healthspan and memory in aging mice

The ketogenic diet improves healthspan and memory in aging mice

A study by the Buck Institute and University of Chile found the ketogenic diet boosts memory in aging mice by enhancing synapse function through a new molecular pathway involving β-hydroxybutyrate. Future research will explore interventions for brain health.

The Limited Value of Multivitamin Supplements

The Limited Value of Multivitamin Supplements

A study in JAMA Network Open found multivitamin supplements did not reduce mortality risk and could increase it by 4%. Obtaining vitamins from food is preferred, with some exceptions for specific health conditions.

Multivitamin does not improve longevity

Multivitamin does not improve longevity

The study on multivitamin use and mortality risk involved 390,000+ participants. Proportional hazards assumption violation led to stratified analysis, emphasizing the complexity of associations and the call for additional research.

The case for omega-3 supplementation to lower aggression

The case for omega-3 supplementation to lower aggression

A meta-analysis by Adrian Raine shows omega-3 reduces aggression by 30% in diverse groups. The study of 29 trials with 3,918 participants supports omega-3's role in curbing violent behavior, suggesting its use alongside existing interventions. Raine advocates for widespread omega-3 implementation to address aggression effectively.

Link Icon 9 comments
By @diob - 5 months
I've worked out my whole life (since around age 14, now over 35) and had periods where I did a lot of supplements like creatine or pre-workout.

I no longer bother with them, although creatine is one of the more well researched / "real" supplements, so you're better off with that than lots of others.

To me though they've never really done anything (besides cost money). In my opinion the best bang for your buck is drinking a coffee before or during your workout. That and make sure you get enough sleep and eat nutritious food.

By @ratg13 - 5 months
If you’ve never tried adding a little bit of creatine in your diet, I would recommend trying it.

You will definitely notice the positive effects.

If you’re not training, don’t take weight lifting amounts, just 500-1000mg a day is more than enough.. more than that and your body will start to get larger because you will be retaining water.

By @whatjadat2 - 5 months
Creatine works exceptionally well for me (43m), I lift and do cardio, a couple of times a week. And if I take creatine, for a couple of weeks, I can see a noticeable improvement in energy, and body composition. It's so cheap, why would you not take it?
By @mattgreenrocks - 5 months
I have creatine on my short list of supplements to try this summer. Anything you wished you knew when starting it? Do I need to worry about buying a specific brand known for being “clean”?
By @burritosnob - 5 months
I'm rapidly approaching 50 and in the gym 7 days a week 2+ hours a day for heavy lifting and cardio.

Creatine is one of the few supplements that I can say has noticeable immediate difference on or off. Without it, my recoveries take longer and I have to back down workouts to 4-5 days a week.

5mg a day... time doesn't seem to make a difference but I take pre workout. No hair loss or other side effects.

By @ekanes - 5 months
Creatine seems acknowledged as working in the fitness community by both the bro-science and the science-based crowds.

For me, it worked very well, but I noticed I was losing hair in the shower (eep!) and stopped using it. Seems that's a thing for people with male pattern baldness. ¯\_(ツ)_/¯

By @Lerc - 5 months
Given the near de facto standard use of creatine for people working out, I would have expected there to be more conclusive results available.
By @anigbrowl - 5 months
Conclusion: Creatine supplementation improves sit-to-stand performance, muscle function, and lean tissue mass. It is crucial to conduct high-quality prospective RCTs to confirm these hypotheses (PROSPERO number, CRD42023354929).

'Give us funding pls'

I use creatine myself and think it helps build muscle, but this is a pretty weak result. I do think it's worth researching because it's a cheap supplement and could help an ageing demographic as part of an exercise program. OTOH I'm not sure it's necessary if you're not exercising intensively or actively trying to build strength. Consistent regular light exercise and reducing sugar in your diet seems like the best way for most people to deal with ageing.

By @n8henrie - 5 months
> The quality of evidence for all outcomes was low or very low because of a high risk of bias.