New computational microscopy technique provides direct route to crisp images

A new computational microscopy technique called Angular Ptychographic Imaging with Closed-form method (APIC) has been developed by a team at the California Institute of Technology. This technique aims to provide clearer and crisper images compared to the existing Fourier ptychographic microscopy (FPM) method. APIC eliminates the iterative nature of the algorithm used in FPM by solving a linear equation to correct aberrations introduced by the microscope's optical system. This approach allows for obtaining high-resolution images with a large field of view without the need for repeated refocusing. The new method, described in a paper published in Nature Communications, has the potential to advance fields such as biomedical imaging, digital pathology, and drug screening. By leveraging insights about the optical system, APIC offers faster, more accurate image reconstruction, making it a promising tool for various imaging systems and potentially optimizing image data input for artificial intelligence applications.