Anti-ageing 'supermodel granny' drug extends life in mice by 25%
A drug targeting interleukin-11 extended lab mice lifespans by 25%, improving health and reducing cancer. Its effects on human ageing are uncertain, despite promising results. Researchers aim to slow ageing by manipulating molecular processes.
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A drug tested on laboratory animals has shown promising results in extending their lifespans by nearly 25%. Dubbed "supermodel grannies" due to their youthful appearance, the treated mice were healthier, stronger, and had fewer instances of cancer compared to their untreated counterparts. The drug targets a protein called interleukin-11, which increases with age and contributes to inflammation and ageing-related processes. While the drug is already being tested in humans, its potential anti-ageing effects remain uncertain. Researchers are exploring ways to manipulate molecular processes to slow down ageing, with this drug being a significant development in the field. Despite the positive outcomes in animal studies, questions remain about its efficacy and safety in humans, as well as the feasibility of widespread use. Other drugs like metformin and rapamycin are also being investigated for their anti-ageing properties. The research, conducted by a team from the MRC Laboratory of Medical Science, Imperial College London, and Duke-NUS Medical School in Singapore, offers a potential avenue for extending healthy ageing in the future.
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8 commentsOn the "lack of evidence in patients" ... does "testing" this in humans mean decades long trials? Given that the effects in their animal model was 25%, it seems like measuring if there was such an increase in humans (and beginning taking it in late middle age) it would be a generation before you had results.
On the "unthinkable to treat every 50-year-old" comment, I think we as a society would need to change as a function of our changed lifespans -- making all the middle-aged people live to 100+ would exacerbate issues around social benefits, housing stock, etc. But if we all had longer, more productive lives (i.e. worked longer, added our skills and expertise to the economy for longer), could that more than offset the costs? If a drug raised your life expectancy by 20 years, and most people worked another 15, that's still pretty good.
Though in seriousness, pretty amazing if this works in humans. Peptide therapy seems huge lately.
It might be useful as a lead to that master regulator, though. Or it might be not.
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'Supermodel granny' drug extends life in animals
A drug targeting interleukin-11 extended lab mice lifespans by 25%, improving health and reducing cancer rates. Human testing is ongoing, with potential anti-ageing effects sparking interest in molecular ageing mechanisms.
Mice live longer when inflammation-boosting protein is blocked
A study in mice shows blocking IL-11 protein increases lifespan by 25%, improves metabolism, and reduces frailty. Human trials for cancer and fibrosis treatment are ongoing. Research suggests IL-11 inhibition could impact human longevity, pending further studies.
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
Researchers found inhibiting IL-11 signaling extends mammal healthspan and lifespan. Deleting Il11 or Il11ra1 in mice protects against aging-related issues. Anti-IL-11 treatment improves metabolism, muscle function, and extends mouse lifespan significantly.
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