July 19th, 2024

Human reproduction comes at the expense of faster aging and a shorter life

A study on human reproduction and aging reveals a trade-off: early childbearing, multiple pregnancies, or childlessness may accelerate aging and increase mortality risk. Genetic and lifestyle factors impacting healthspan are highlighted.

Read original articleLink Icon
Human reproduction comes at the expense of faster aging and a shorter life

The study published on bioRxiv explores the trade-off between reproduction and aging in humans. Analyzing data from Finnish twin women, researchers found that early childbearing, multiple pregnancies, or not having children can lead to accelerated aging and increased mortality risk. The study, involving 17,080 women, also used a biological aging algorithm to assess participants, revealing a link between reproductive trajectories and survival. These findings support the idea of a trade-off between reproduction, aging, and lifespan in modern humans. The research sheds light on the genetic and lifestyle factors influencing healthspan. The authors disclosed no competing interests.

Related

Five years later, naked mole-rat mortality rates still defy Gompertzian laws

Five years later, naked mole-rat mortality rates still defy Gompertzian laws

Researchers discovered naked mole-rats defy aging laws, showing no mortality increase with age. Data doubling over five years supported this, contrasting with Damaraland mole-rats. Naked mole-rats resist age-related diseases, challenging demographic aging concepts.

New insights into transcription factors and chromatin remodeling

New insights into transcription factors and chromatin remodeling

Researchers at the University of Queensland reveal insights on aging control mechanisms, focusing on transcription factors and chromatin remodeling. AP-1 plays a key role in gene regulation, offering potential for age-related disease interventions and healthspan enhancement.

Groundbreaking study reveals the impact of genetics on IQ scores over time

Groundbreaking study reveals the impact of genetics on IQ scores over time

A study by Nancy L. Segal in Personality and Individual Differences reveals genetic factors' increasing influence on intelligence as individuals age. Research on reared-apart twins highlights genetics' role in shaping intellectual abilities over time.

'Supermodel granny' drug extends life in animals

'Supermodel granny' drug extends life in animals

A drug targeting interleukin-11 extended lab mice lifespans by 25%, improving health and reducing cancer rates. Human testing is ongoing, with potential anti-ageing effects sparking interest in molecular ageing mechanisms.

Anti-ageing 'supermodel granny' drug extends life in mice by 25%

Anti-ageing 'supermodel granny' drug extends life in mice by 25%

A drug targeting interleukin-11 extended lab mice lifespans by 25%, improving health and reducing cancer. Its effects on human ageing are uncertain, despite promising results. Researchers aim to slow ageing by manipulating molecular processes.

Link Icon 4 comments
By @keiferski - 3 months
(Apologies for the rambling comment, this is just a thought I’ve had and this link reminded me of it.)

One interesting way of thinking about the last few hundred years, specifically the growth of individualism, is that it’s a shift of focus from larger social organisms (the family, the village, the nation, etc.) to the individual person’s organism. Which is an obvious description of individualism, of course, but it has sorts of downwind effects that maybe aren’t as immediately apparent.

This occurred to me when I was reading about some life extension organizations trying to make individuals’ lives longer. It’s not about being remembered or honored by society, or about continuing a legacy via a family/business/institution/etc. but about extending your personal experience longer.

If we went back to a different civilization like the Romans, the dynamic was very different. There was much less focus on extending the individual life experience and more focus on being honorably remembered by Roman society. A desirable afterlife was one in which you were honored by society, not one in which your personal experience continued forever.

What is really interesting though is how these two dynamics (individuals vs. groups) will play out in the future, evolutionarily. I can’t imagine that individualism’s limits are endless; at some point group dynamics would become more competitive, I think. And yet at the same time a lot of resources are going into the extension of individual lifespans.

To put this all another way: imagine two opposite societal structures. One is comprised of individuals that live extremely long, focus on their personal experience, and assume they will be largely forgotten after death - partially because of the unpredictability of the future. The other is comprised of people that live shorter lives, are focused more on the social group (and have more kids), and are remembered after their deaths for their contributions to that group. They buy in to this vision because the future is more predictable.

It seems like the last few hundred years in the West has been a shift from group 2 to group 1, but it remains to be seen if that will continue.

By @hereme888 - 3 months
Having no children was also associated with reduced lifespan. That's the worst one of all. I'd rather die a bit younger but have offspring.
By @SubiculumCode - 3 months
Bah. Middle-class and wealthy have fewer children than do the poor, and likewise shorterlifespans, in other news.
By @timetraveller26 - 3 months
but what if I am not a Finnish twin woman?