Antidepressants sexual side-effects, SSRI sexual dysfunction, serotonin syndrome

Depression and anxiety are prevalent mental health issues, affecting one in six individuals weekly, with 8.32 million people in the UK prescribed antidepressants. Those living with HIV are particularly vulnerable, with a higher incidence of depression and anxiety, and an estimated one in three experiencing these conditions. Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are associated with significant sexual side effects, including anorgasmia, reduced libido, vaginal dryness, and erectile dysfunction, which can cause considerable distress. The phenomenon of post-SSRI sexual dysfunction (PSSD) is gaining attention, as symptoms may persist long after discontinuation of the medication, leading to issues such as genital numbing and a lack of sexual pleasure. Advocacy groups are working to raise awareness and funding for research into PSSD, highlighting the need for better understanding and management of these side effects. The British National Formulary categorizes the prevalence of sexual side effects from antidepressants as common to very common, affecting more than ten percent of users. This raises ethical concerns regarding informed consent in prescribing practices, as patients must be adequately informed about potential risks and side effects. The General Medical Council emphasizes the importance of tailored consultations to ensure patients understand their treatment options and associated risks. Overall, the review underscores the necessity for healthcare professionals to be aware of these issues to improve patient care and outcomes, particularly for those with complex health backgrounds such as HIV.