Revolutionary Dual Action Antibiotic Makes Bacterial Resistance Nearly Impossibl
Researchers at the University of Illinois Chicago have developed macrolones, synthetic antibiotics that disrupt protein production and DNA structure, making it harder for bacteria to develop resistance.
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Researchers at the University of Illinois Chicago have developed a new class of synthetic antibiotics known as macrolones, which target bacterial infections by disrupting both protein production and DNA structure. This dual-action approach makes it significantly more challenging for bacteria to develop resistance, with estimates suggesting it could be 100 million times harder for them to do so. The study, published in Nature Chemical Biology, highlights how macrolones can simultaneously interfere with two critical cellular mechanisms, thereby complicating the bacteria's ability to evolve defenses against the antibiotic.
The research team, led by professors Alexander Mankin and Yury Polikanov, found that macrolones bind more effectively to bacterial ribosomes than traditional macrolides and can inhibit ribosomes from macrolide-resistant strains without triggering resistance genes. The findings indicate that by targeting both the ribosome and DNA gyrase, a specific enzyme in bacteria, macrolones could prevent the emergence of drug-resistant strains. The study emphasizes the importance of optimizing these antibiotics to ensure they effectively hit both targets. This interdisciplinary research reflects collaboration across various scientific fields at UIC, aiming to advance the understanding and development of new antibiotics to combat infectious diseases. The study was supported by multiple national and international funding agencies.
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A new class of antibiotics, macrolones, shows promise against antimicrobial resistance by using a dual-target approach. Developed by researchers, they effectively combat resistant bacteria, offering hope for future treatments.
Dual action antibiotic could make bacterial resistance nearly impossible
Researchers at the University of Illinois Chicago developed macrolones, a new antibiotic class that targets protein production and DNA structure, significantly reducing bacterial resistance and showing promise for further development.
Dual-action antibiotic could make bacterial resistance nearly impossible
Researchers at UIC developed macrolones, a dual-action antibiotic that targets bacterial functions, making resistance 100 million times harder. This approach shows promise in combating antibiotic resistance effectively.
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