Brain wiring is guided by activity even in early development
A Yale University study shows that brain wiring begins before birth, driven by spontaneous cellular activity. Synchronization of neuronal firing enhances connectivity, supporting Hebb's rule. Future research will explore axon branching persistence.
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A recent study from Yale University has revealed that the wiring of the brain in humans begins even before birth, guided by spontaneous cellular activity rather than sensory experiences. Researchers focused on mouse retinal ganglion cells, which connect to the superior colliculus in the brain. They found that when these cells fire in synchrony with surrounding cells, it promotes the growth of new axon branches, enhancing connectivity. This phenomenon aligns with Hebb's rule, which posits that connections between neurons are strengthened when they activate together. The study utilized advanced microscopy techniques to observe these processes in awake neonatal mice whose eyes had not yet opened. The findings suggest that similar mechanisms may govern brain wiring in other neural circuits, such as the spinal cord and hippocampus. Future research will investigate whether these axon branching patterns persist after sensory experiences begin and how they affect downstream neurons. This work contributes to understanding the fundamental rules and mechanisms of brain development.
- Brain wiring starts before birth, driven by spontaneous cellular activity.
- Synchronization of neuronal firing strengthens connections between cells.
- The study supports Hebb's rule, which applies to both learning and early brain development.
- Advanced microscopy techniques were used to observe cellular activity in neonatal mice.
- Future research will explore the persistence of axon branching patterns after sensory experiences.
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1 commentsSo the opportunity to "fire together" is being driven by an underlying brain mechanism.
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