Metabolic brain boost revives memory in Alzheimer's mice

Researchers have discovered that an experimental cancer drug can reverse memory loss in mice with Alzheimer's disease by enhancing brain metabolism. The study, published in the journal Science, indicates that the drug helps the brain convert glucose into energy, which is crucial for cognitive functions. Unlike current Alzheimer’s treatments that target amyloid plaques, this new approach focuses on restoring energy levels in the brain. The research originated from an unexpected finding when scientists at Stanford University removed an enzyme called IDO1, which they believed was hindering brain metabolism. Surprisingly, the absence of IDO1 improved the mice's ability to learn and remember. The drug used in the study mimics this genetic alteration, leading to enhanced energy production in astrocytes, the brain cells that support neurons. This suggests that Alzheimer’s involves more than just amyloid plaques and that metabolic changes in the brain can be reversible. The findings propose a potential new avenue for Alzheimer’s treatment that could complement existing therapies by improving memory and cognitive function, although further research is needed to confirm these results in humans.

- An experimental cancer drug has shown promise in reversing memory loss in Alzheimer’s mice by boosting brain metabolism.

- The study highlights the role of astrocytes in supporting neurons and suggests that metabolic changes in the brain can be reversible.

- Current Alzheimer’s treatments focus on amyloid plaques, while this new approach targets energy production in the brain.

- The findings indicate a need for further research to explore the drug's effects in human subjects.

- This research could lead to combined therapies that improve cognitive function alongside existing Alzheimer’s treatments.