September 7th, 2024

Exercise May Be the Most Potent Medical Intervention Ever Known

Exercise is recognized as a vital medical intervention, reducing disease risk and potentially extending lifespan. Research explores its molecular mechanisms, aiming to develop medications that replicate exercise benefits.

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Exercise May Be the Most Potent Medical Intervention Ever Known

Exercise is increasingly recognized as a powerful medical intervention, with significant benefits for both physical and mental health. Euan Ashley, a professor at Stanford, emphasizes that exercise can reduce the risk of various diseases, including diabetes, certain cancers, and mental health issues. Research indicates that engaging in physical activity can lead to a remarkable statistic: one minute of exercise may extend life by five minutes. This correlation is based on extensive observational studies involving large populations. Despite the known benefits, the precise molecular mechanisms by which exercise exerts its effects remain largely unexplored. Ashley's research aims to bridge this gap, investigating how exercise impacts the body at a cellular level. The findings could potentially lead to the development of "exercise pills" that replicate the benefits of physical activity without the need for actual exercise. Overall, the conversation highlights the importance of understanding exercise not just as a lifestyle choice but as a critical component of health care.

- Exercise is one of the most effective interventions for preventing disease and improving mental health.

- One minute of exercise may increase lifespan by five minutes, according to research.

- The molecular mechanisms of how exercise benefits health are still being studied.

- There is potential for developing medications that mimic the effects of exercise.

- Understanding exercise's impact can enhance its role in health care and personal wellness.

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Link Icon 14 comments
By @0xcde4c3db - 6 months
> On the one hand, physical activity is clearly one of the best interventions for preventing physical disease and mental suffering

As far as I've read, it's decidedly unclear that general physical activity as an intervention is proven for much of anything; as Dr. Ashley mentions, most of the data we have is from observational studies. I think it's fair to say that for the vast majority of people, a moderate amount of physical activity is almost certainly better overall than being a total couch potato. But it's also not as simple as "active good, sedentary bad". In particular, I've seen a few studies suggesting that physical activity at one's job might not have the same disease-prevention benefits as physical activity for leisure (e.g. [1]), which casts some doubt on the idea that the benefits are primarily coming from physical activity per se.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621902/

By @unsupp0rted - 6 months
This doesn't make sense to me, evolutionarily.

Why do I hate going to the gym / lifting weight & cardio so much? Why do I feel no obvious benefits from a month of 4-days a week of weight training (apart from some extra strength & minor visible changes)?

If exercise is so potent and so beneficial, then shouldn't I crave it the way I crave sugar? Or at least not actively dislike it?

By @guitarlimeo - 6 months
Totally agree. Once I started lifting weights a lot of my internal struggles became easier to deal with, and if I don't go to the gym for a week those become hard again. I would probably put it even before sleep in importance (if your not an insomniac, and probably even then) as it helps with your sleep too.
By @ck2 - 6 months
It's critical in life but there are limits to what exercise can do of course

I've been trying to run myself out of long-covid for four years now, doesn't work

Anyway that's an odd website to link to when there are endless studies and papers on this

https://www.sciencedirect.com/science/article/pii/S009286741...

By @Horffupolde - 6 months
“Exercise” is just an integral part of life, like eating and sleeping. Just because it can’t be reductionistically understood doesn’t mean it’s not necessary.
By @amai - 6 months
„One minute of exercise buys you five minutes of extra life.“

It is not that easy:

“While it may be unsurprising to hear a boxer is more likely to live a shorter time than the average man, it is more shocking to learn how tennis players continue to live longer as the years pass, and that, despite advances in medicine and technology, footballers are less likely now than in the 1930s to live longer. This research also confirms that social factors – such as socio-economic background and level of education – have a key influence on longevity.”

https://ilcuk.org.uk/top-level-sportsmen-may-live-13-per-cen...

By @carlgreene - 6 months
Moving, as the body is intended to do, is exceptionally good for it?

Who would have thought!

By @helph67 - 6 months
"Unfortunately, diet, exercise, and sleep are so deeply intertwined, it is not possible to say that one is more important than the others" https://www.sleepfoundation.org/physical-health/diet-exercis...
By @mensetmanusman - 6 months
Try standing more than you sit during the day as a first step.
By @guerrilla - 6 months
Brains a for moving.
By @PaulKeeble - 6 months
Exercise research might be the area of medical research with the most fraud ever known. The amount of papers in this field showing effects that never materialise is astounding.