September 22nd, 2024

The unknowns surrounding the mysterious rise of cancer in young adults

Cancer cases in young adults have surged by nearly 80% in 30 years, with lifestyle factors contributing. Experts call for increased awareness, education, and revised screening guidelines for early detection.

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The unknowns surrounding the mysterious rise of cancer in young adults

The rise of cancer in young adults has become a significant concern for oncologists, with a nearly 80% increase in tumors among individuals under 50 over the past 30 years. This trend was highlighted at the recent European Society for Medical Oncology (ESMO) congress in Barcelona, where experts discussed the potential causes, including lifestyle factors, though these do not fully explain the phenomenon. Colorectal cancer is particularly prevalent, but other types, such as pancreatic and breast cancer, are also on the rise. Many young patients present with tumors similar to those found in older adults, complicating the understanding of early-onset cancer. Factors such as unhealthy diets, sedentary lifestyles, and exposure to risk factors from childhood are believed to contribute, but the exact causes remain unclear. The lack of early detection tests for younger populations often leads to later diagnoses, which can result in more aggressive tumors and poorer prognoses. Experts emphasize the need for increased awareness, lifestyle education, and potential adjustments to screening guidelines. They also stress the importance of seeking medical attention for any concerning symptoms, as early diagnosis can significantly impact treatment outcomes and quality of life.

- Cancer cases in young adults have increased by nearly 80% in the last 30 years.

- Lifestyle factors, including diet and exercise, are significant contributors but do not fully explain the rise.

- Many young patients are diagnosed at advanced stages due to a lack of early detection tests.

- There is a need for increased awareness and education regarding cancer symptoms in younger populations.

- Experts advocate for potential changes in screening guidelines to address early-onset cancers.

Link Icon 19 comments
By @golanggeek - 7 months
> The BMJ Oncology study concludes that “dietary risk factors, alcohol consumption, and tobacco use were the main risk factors for major early-onset cancers.” But it adds that “prospective lifetime cohort studies are needed to explore the etiologies [causes] of early-onset cancers.”

> In the UK, specialists have specifically flagged up the risks of processed foods, which includes ready-made meals and pizzas, which young people tend to consume more of.

Food seems to be the main culprit..

By @Aardwolf - 7 months
Tangentially related question: one cause of cancer would be lack of physical activity (https://www.who.int/news-room/fact-sheets/detail/cancer).

What's the mechanism of this? Cancer is caused by bad-luck random cell division creating a bad cell, I can see how chemicals influence this process, but how does physical activity?

By @candiddevmike - 7 months
> The BMJ Oncology study concludes that “dietary risk factors, alcohol consumption, and tobacco use were the main risk factors for major early-onset cancers.” But it adds that “prospective lifetime cohort studies are needed to explore the etiologies [causes] of early-onset cancers.”

Whatever we're consuming is most likely the culprit (or whatever is being sprayed on/injected into/fed to what we're consuming).

By @AtlasBarfed - 7 months
Exercise/fitness/activity would be primary suspicion, which is also diet. You need a very high level of activity in order to properly exist in today's high carbohydrate corn syrup food base

Permoplastics might have a roll but you figure that would have showed up by now a lot earlier.

It could also be binge drinking. The culture of binge drinking has been steadily compounding itself over several generations of college students. But that may be an American phenomenon. This is a global one and it may not apply.

By @pvaldes - 7 months
The study cited is "Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019". BMJ Oncology. 2023.

Important context lacking here is that a scientist called Jianhui Zhao, has been caught cheating previously in a 2018 article about cancer. Results didn't matched the experiments.

https://pubmed.ncbi.nlm.nih.gov/33901310/

"certain of the Transwell cell migration and invasion assay data shown in Fig. 3B were strikingly similar to data appearing in different form in a pair of other articles written by different authors at different research institutes, one of which had already been published elsewhere prior to the submission of this paper to International Journal of Molecular Medicine"

--If-- this author from the Second Affiliated Hospital on Zhejiang (China) is the same person that worked previously on the Hospital of Jilin University (China), we should take the results claimed here with a healthy dose of caution.

By @dathos - 7 months
Anyone aware of the possible correlation between this and forever chemicals found in humans increasing? I don’t see it mentioned in the article
By @walthamstow - 7 months
> people born in 1990 [have] a significantly higher rate of developing colorectal cancer compared to people born in 1950

Wow. As someone born in 1990 +/- 2 years that's a statistic that will fester in ny mind.

By @mglz - 7 months
The article seems to skip over the pandemic, which has changed behaviours significantly. Also, the Coronavirus itself is suspected to promote cancer [1].

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202899/

By @woodpanel - 7 months
Ok, since many comments chip in subjective suggestions of who the culprit might be, here are my unsubstantiated reasons for rising cancer rates in young adults:

china [1] higher education [2]

[1] having spent time in China and seen how there is simply no remorse selling toxic waste as food, toys or skin care products I can’t see how western households, which are overproliferated with cheap goods made in China (i’d say 95% of everything a Westerner owns is made in PRC), aren’t affected by it. Put differently, why would China wait for its demographic Overton window to close and let its empire buildup be hampered by health concerns, let alone those of foreigners?

[2] inflationary amounts of degree holders create more toxicity in the womb: Eggs are older and the mothers under a lot more stress (both parents need to work, societal pressure to not just excel in classic female fields, but also classic male domains, specifically academia)

By @capitainenemo - 7 months
One more possibility to throw on the pile.. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860074/
By @cjbgkagh - 7 months
I think it’s from dysautonomia impairing the immune system. Pretty much anything that affects the autonomic nervous system, which is a huge number of very different things, can trigger dysautonomia. The rational for my reasoning is that the propensity for cancer appears to occur at roughly the same rate as the propensity for dysautonomia regardless of the cause of dysautonomia.

Covid and the Covid Vaccine are both triggers for dysautonomia, I presume because both use the spike protein. The vaccine triggered mine but I have a strong genetic propensity for it anyway with multiple inherited anxiety disorders.

By @maherbeg - 7 months
There’s been another hypothesis around the wider spread use of emulsifiers, specifically in lower fat foods. Lots of people are eating “healthy” almost whole food sources that contain them.
By @TacticalCoder - 7 months
From when to when? What is badly needed is statistics before Covid hit and after Covid hit.

And statistics by countries and depending on who got which vaccine and compared to people who didn't get the vaccine.

P.S: FWIW I got the mRNA one from Pfizer/BioNTech and had I know what I know today I'd never have taken it.

By @m3kw9 - 7 months
All the crap drinks they are promoting to young kids like Prime or redbull so prevailent in social media could be a factor
By @swayvil - 7 months
The vaccine?
By @logicchains - 7 months
Climate change strikes again. It has no end of unexpected consequences.