November 20th, 2024

Cells have more mini 'organs' than researchers thought

Recent research indicates that cells have more membraneless organelles, called biomolecular condensates, than previously known, which may reshape theories on life's origins and aid in medical advancements.

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Cells have more mini 'organs' than researchers thought

Recent research has revealed that cells contain more membraneless organelles, known as biomolecular condensates, than previously understood. These organelles, which do not have a surrounding membrane, challenge traditional views of cell organization and function. Unlike the well-known membrane-bound organelles, such as mitochondria and lysosomes, biomolecular condensates form through the clustering of proteins and RNA, creating gel-like droplets that act as unique biochemical compartments. Approximately 30 types of these condensates have been identified, compared to around a dozen membrane-bound organelles. Their functions vary, with some playing roles in reproductive cells and stress responses, while others remain poorly understood. The presence of biomolecular condensates in bacterial cells suggests a greater complexity in prokaryotic life than previously recognized. Additionally, these findings may reshape theories about the origins of life, as they imply that RNA could have formed and organized without the need for lipid membranes. This research also holds potential for medical advancements, particularly in understanding and treating diseases like Alzheimer’s and Huntington’s. As scientists continue to explore the roles of these condensates, it is likely that they will redefine fundamental concepts in biology.

- Cells contain more membraneless organelles than previously thought.

- Biomolecular condensates challenge traditional views of cell organization.

- These organelles may play diverse roles, some of which are still unknown.

- Their discovery could reshape theories about the origins of life.

- Research on condensates may lead to new medical treatments.

Link Icon 4 comments
By @chrsw - 5 months
This is one reason why I'm dismayed when people interested in the origin of life question start talking about cells. They're too complex. I think Nick Lane something like "if you were size of a molecule and you stood on the edge of a cell you'd see something about as complex as a city laid out before you". Imagine wanting to understand the origins of human civilization and you start out by studying Miami or Seattle.
By @OutOfHere - 5 months
Hopefully this presents many more avenues for measuring, understanding, and healing dysfunctions and diseases.
By @Rochus - 5 months
This is already known for a long time; see also https://en.wikipedia.org/wiki/Biomolecular_condensate.