Hypothalamic deep brain stimulation augments walking after spinal cord injury

A recent study published in Nature Medicine explores the potential of hypothalamic deep brain stimulation (DBS) to enhance walking recovery in individuals with spinal cord injury (SCI). The research identifies the lateral hypothalamus (LH) as a critical brain region involved in the recovery of walking after incomplete SCI. By stimulating glutamatergic neurons in the LH, researchers found that walking ability improved significantly in animal models, with effects persisting even after stimulation was ceased. A pilot clinical trial involving two participants with incomplete SCI demonstrated immediate improvements in walking following DBSLH, alongside enhanced functional recovery when combined with rehabilitation efforts. Importantly, no serious adverse events were reported during the study. These findings suggest that targeting specific brain regions through DBS could optimize the engagement of spinal cord-projecting neurons, potentially leading to better recovery outcomes for individuals with SCI. Further research is needed to assess the long-term safety and efficacy of this approach, including its impact on various physiological and psychological parameters.

- Hypothalamic deep brain stimulation shows promise in improving walking recovery after spinal cord injury.

- The lateral hypothalamus is identified as a key brain region for facilitating recovery.

- Animal studies indicate that stimulation leads to immediate and lasting improvements in walking.

- A pilot clinical trial confirms immediate benefits in two human participants with incomplete SCI.

- Further studies are required to evaluate the long-term safety and efficacy of this treatment approach.