Mapping the biology of spinal cord injury in unprecedented detail

Researchers at EPFL have made a groundbreaking advancement in understanding spinal cord injuries (SCI) by creating an open-source 'atlas' called 'Tabulae Paralytica'. By combining advanced molecular mapping technologies and artificial intelligence, they have provided a detailed insight into the cellular and molecular dynamics of paralysis in mice. This project, published in Nature, identifies key neurons and genes crucial for recovery and proposes a gene therapy based on these findings. The study challenges traditional views on astrocytes, suggesting their potential in repairing spinal cord injuries. Additionally, a specific subset of neurons, Vsx2 neurons, has been highlighted for their role in promoting recovery. The research utilized single-cell sequencing and spatial transcriptomics technologies to create a comprehensive cellular map of SCI in rodent models. The data, analyzed with AI, offers a detailed understanding of cellular interactions during injury and recovery, paving the way for personalized and effective treatments. While conducted in rodents, the study's insights are expected to have clinical applications, building on EPFL's decade-long progress in SCI research.