New technique opens the door to large-scale DNA editing to cure diseases
Researchers have described a new genetic editing mechanism using jumping genes to insert DNA sequences accurately. This system shows promise in overcoming CRISPR limitations, with 94% accuracy and 60% efficiency in bacteria. Optimizations are needed for mammalian cell use.
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A new genetic editing mechanism has been described in two articles published in the journal Nature, offering a potentially more precise way to introduce long DNA sequences into specific places in the genome. This technique, using jumping genes or transposable elements, allows for the reprogramming of RNA bridges to insert desired DNA sequences accurately. The system has been tested in bacteria, showing an accuracy of 94% and an insertion efficiency of 60%. Researchers believe this method could overcome some of the limitations of current CRISPR systems, offering safer gene-editing outcomes by avoiding large deletions or unwanted translocations at the cut site. While the new technique shows promise in modifying larger genome regions, it still has limitations such as variable efficacy and potential modifications in other genomic locations. Further optimization may improve its efficacy, but its applicability in mammalian cells remains to be seen. Scientists are optimistic about the therapeutic potential of this new DNA editing system beyond the capabilities of current CRISPR technologies.
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