Gut inflammation associated with age and Alzheimer's disease:human cohort (2023)
Researchers found elevated calprotectin levels in older adults with Alzheimer's disease (AD) pathology. Higher levels were linked to increased amyloid burden, suggesting a connection between gut inflammation and AD progression, urging more investigation.
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Researchers conducted a human cohort study to investigate the association between gut inflammation, age, and Alzheimer's disease (AD) pathology. They analyzed fecal samples from older adults, measuring calprotectin as a marker of intestinal inflammation. The study revealed that calprotectin levels were elevated in advanced age and higher in participants diagnosed with amyloid-confirmed AD dementia. Among individuals with AD dementia, higher calprotectin levels were associated with greater amyloid burden. The findings suggest a link between intestinal inflammation and brain pathology, even in the early stages of AD. The study also indicated associations between calprotectin levels and cerebrospinal fluid markers of AD, as well as lower verbal memory function in cognitively unimpaired participants. These results highlight the potential role of intestinal inflammation in exacerbating the progression towards AD, emphasizing the importance of further research in this area.
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