Alzheimer's Risk Is Strongly Shaped by Your Mother's Side, Study Finds
A study in JAMA Neurology reveals Alzheimer's genetic risk is more influenced by maternal history. Mitochondria dysfunction from the mother's side may play a role. Gender-specific parental history is crucial for identifying risk factors.
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A recent study has found that the genetic risk of developing Alzheimer's disease is more strongly influenced by the mother's side than the father's side. The study, published in JAMA Neurology, analyzed data from over 4,000 individuals and revealed that those with a maternal history of memory loss had a higher risk of Alzheimer's, regardless of age, compared to those with only a paternal history. Participants with fathers experiencing early-onset memory loss also showed increased risk. The study suggests that mitochondria dysfunction inherited from the mother's side could be a contributing factor. This research emphasizes the importance of considering gender-specific parental history in identifying Alzheimer's risk. While genetics play a critical role, modifiable risk factors like diabetes and cardiovascular disease also significantly contribute to the disease. Further investigation into the influence of maternal DNA, particularly the X chromosome, and mitochondria dysfunction could provide valuable insights for future treatments.
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1 commentsOn a population scale, I expect virtually all heritable traits to correlate more strongly with maternal family history than with paternal family history, simply because some portion of the population are (unbeknownst to them) not actually genetically related to their dads.
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