Claustrum neurons projecting to the anterior cingulate restrict engagement
Researchers found claustrum neurons projecting to ACCp regulate engagement levels in sleep and wakefulness. Increased activity reduced sensory responsiveness during sleep and affected attention tasks. ACCp activation improved sleep quality and task performance.
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Researchers have discovered that neurons in the claustrum region of the brain, specifically those projecting to the anterior cingulate cortex (ACCp), play a crucial role in regulating engagement levels during both sleep and wakefulness. By studying mice, they found that heightened activity in these neurons led to reduced sensory responsiveness during sleep and correlated with disengagement and behavioral lapses during an attention task. Elevating ACCp activity through chemogenetic methods decreased awakenings during sleep and impulsive errors in the task. The study also revealed that mice using an exploration strategy showed a stronger correlation between ACCp activity and task performance compared to those using an exploitation strategy. These findings suggest that ACCp claustrum neurons are involved in restricting engagement during sleep and goal-directed behavior, highlighting their role in modulating sensory responsiveness across different behavioral states.
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