Study shows ancient viruses fuel modern-day cancers
A University of Colorado study found ancient viruses, reactivated in modern cancers, influence gene expression. Silencing them affects cancer cell behavior, suggesting new treatment strategies targeting these retroviruses for improved outcomes.
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A study conducted by the University of Colorado at Boulder reveals that ancient viruses, known as endogenous retroviruses, can play a crucial role in modern-day cancers when reactivated. These viruses, previously considered dormant, were found to be active in various cancer types, including lung and colon cancer. Silencing these retroviruses showed a significant impact on cancer cell behavior, turning off genes that promote cancer growth. The research suggests that these ancient viruses can act as switches that control gene expression, potentially influencing cancer development and response to treatments. The study also indicates that existing cancer therapies, such as MAP-kinase inhibitors, may work by targeting these reactivated retroviruses. The findings shed light on how ancient viral DNA remnants in the human genome can impact health and disease, offering insights into potential new strategies for cancer treatment.
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