Cellular Reprogramming Improves Cognition in Aged Rats
Researchers found that prolonged expression of reprogramming factors improved cognitive function and reduced epigenetic age in aged rats, suggesting potential therapeutic approaches for age-related cognitive decline. Further research is needed.
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Researchers have demonstrated that prolonged expression of reprogramming factors can counter cognitive decline in aged rats and potentially reduce their epigenetic age. This study, published in GeroScience, involved delivering viral vectors containing the four classic reprogramming factors (OSKM) into the hippocampi of aged female rats. Following a month of treatment, cognitive function was assessed using the Barnes memory test, revealing that untreated aged rats exhibited significant cognitive decline compared to younger counterparts. The OSKM-treated rats showed notable improvements in learning and memory, although they did not reach the performance levels of younger rats. The expression of OSKM genes persisted for at least four weeks without causing pathological changes in the brain. Additionally, the treatment appeared to induce mild rejuvenation, as indicated by three different epigenetic clocks measuring DNA methylation patterns. The findings suggest that interrupted reprogramming may have beneficial effects on cognitive function and epigenetic rejuvenation in the brain. The study highlights the potential of cellular reprogramming as a therapeutic approach to address age-related cognitive decline, although further research is needed to refine safe and effective reprogramming protocols. The results contribute to a growing body of literature supporting the idea that cellular reprogramming can positively impact aging processes in the brain.
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