Weight-loss power of oats naturally mimics popular obesity drugs

A recent study led by researchers at the University of Arizona has found that beta-glucan, a type of fiber abundant in oats, may mimic the weight-loss effects of popular obesity medications like Ozempic. The study focused on how different fibers affect gut microbiota and metabolic health. Mice fed a high-fat, high-sucrose diet supplemented with 10% beta-glucan showed significantly lower weight gain and fat mass, along with higher lean mass compared to those on other fiber diets. These mice also exhibited improved insulin sensitivity and better blood glucose levels over the 18-week study period. The beneficial effects were linked to changes in gut bacteria and the production of metabolites, particularly butyrate, which is known to stimulate the release of appetite-regulating hormones like GLP-1. This suggests that dietary fiber, specifically beta-glucan, can enhance metabolic health and aid in weight management without the side effects associated with pharmaceutical options. The findings highlight the potential of oats and similar foods in combating obesity and improving overall health. The researchers aim to develop enhanced fibers that could further boost butyrate production during digestion. The study was published in The Journal of Nutrition.