The Calorie-Restriction Experiment (2009)
The Calorie-Restriction Experiment (Calerie) studies the effects of a 25% caloric intake reduction on aging and diseases in 132 participants, showing potential benefits for cardiovascular health and cancer risk.
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The Calorie-Restriction Experiment, known as Calerie, is a clinical trial funded by the National Institutes of Health, involving 132 participants from Boston, St. Louis, and Baton Rouge. The study aims to investigate the effects of a 25% reduction in daily caloric intake over two years on aging and associated diseases, rather than focusing solely on weight loss. Participants, who began with a normal to slightly overweight body mass index, are monitored for changes in health markers such as inflammation, insulin levels, and blood pressure. Early results indicate that calorie restriction may significantly reduce cardiovascular risk factors and potentially lower cancer risks.
The study is particularly interested in distinguishing between primary aging, the natural cellular damage that occurs over time, and secondary aging, which encompasses diseases prevalent in older adults. Previous animal studies have shown that calorie restriction can extend lifespan and improve health, but the applicability to humans remains uncertain. Researchers are also exploring the psychological aspects of long-term caloric restriction, questioning whether individuals can maintain such a diet without adverse effects. The trial seeks to determine if calorie restriction can be a viable method for promoting healthier aging and reducing disease risk in humans, while also assessing the feasibility of implementing such dietary changes in everyday life.
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