Male autism is linked to brain aromatase disruption by maternal bisphenol A
A study in Nature Communications links prenatal bisphenol A exposure to increased autism symptoms in males, highlighting brain aromatase disruption and suggesting potential reversibility through nutritional interventions like 10HDA.
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The study published in Nature Communications investigates the relationship between prenatal exposure to bisphenol A (BPA) and autism spectrum disorder (ASD) in males, focusing on the role of brain aromatase disruption. The research, conducted on a cohort from the Barwon Infant Study, found that higher maternal BPA levels during pregnancy correlated with increased ASD symptoms in male children, particularly those with low genetic activity of the aromatase enzyme. The study demonstrated that BPA exposure led to changes in the methylation of the aromatase gene, which in turn affected brain-derived neurotrophic factor methylation. In animal models, male mice exposed to BPA exhibited ASD-like behaviors and brain abnormalities, which were alleviated by administering 10-hydroxy-2-decenoic acid (10HDA), an estrogenic fatty acid. This suggests that the negative effects of BPA on brain development and behavior may be reversible through nutritional interventions. The findings highlight the potential impact of environmental endocrine disruptors on neurodevelopmental disorders and underscore the importance of considering sex differences in ASD research.
- Prenatal BPA exposure is linked to increased ASD symptoms in males with low aromatase activity.
- BPA disrupts aromatase function, leading to neurodevelopmental changes.
- 10HDA may reverse ASD-like behaviors in BPA-exposed male mice.
- The study emphasizes the role of environmental factors in ASD prevalence.
- Findings suggest a need for further research on sex-specific mechanisms in ASD.
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Male autism spectrum disorder is linked to prenatal BPA
A study in Nature Communications links prenatal bisphenol A exposure to increased autism symptoms in males, particularly with low aromatase activity, suggesting potential interventions with 10-hydroxy-2-decenoic acid.
5 commentsThere's also a suggestion that women have more social pressure/conditioning to act a certain way and thus are more efficient at an early age at "masking" symptoms of ASD and less likely to get an opportunity to be tested. Maybe there can be multiple suggestions though (yes, rtfad).
There is some awareness of BPAs role in affecting the endocrine system. As the paper mentions merely being BPA-free doesn't mean one is out of the woods. All bisphenols are to some extent as disruptive as BPA is. Hadn't known that.
There's a list of other bisphenols here: https://en.wikipedia.org/wiki/Bisphenol
BPAs and modern vaccines have been around for roughly the same length of time, so I find it interesting that the random facebook posts being spread about saying "there wasn't as much autism in olden times because they didn't have vaccines" might have been at least a little bit accurate, even if they were wrong about the cause(vaccines).
Also, BPAs have a lot of other affects and frankly shouldn't be allowed, even if this study isn't replicable.
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