September 5th, 2024

The Ultra-Selfish Gene

CRISPR/Cas9 technology allows precise genetic modifications and gene drives to potentially eradicate malaria-carrying mosquitoes, but raises ethical concerns about ecological impacts and the need for monitoring and reversal drives.

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The Ultra-Selfish Gene

The article discusses the potential of CRISPR/Cas9 gene editing technology, particularly its application in creating gene drives that can modify entire populations, such as malaria-carrying mosquitoes. The CRISPR system, initially discovered in bacteria, allows for precise DNA editing by utilizing a guide RNA to direct the Cas9 protein to specific DNA sequences. This technology can be harnessed to create gene drives that ensure a gene is passed on to nearly all offspring, potentially leading to the eradication of species that pose health risks, like mosquitoes that transmit malaria. However, the power of gene drives raises ethical concerns, as they could unintentionally disrupt ecosystems if misused. The article also highlights the concept of reversal drives, which could counteract harmful gene drives by replacing them with original genes. The ability to detect CRISPR modifications in species, particularly in humans, is also discussed, emphasizing the importance of monitoring and controlling gene editing technologies to prevent ecological disasters.

- CRISPR/Cas9 technology enables precise genetic modifications and the creation of gene drives.

- Gene drives can spread specific traits through populations, potentially eradicating harmful species like malaria-carrying mosquitoes.

- Ethical concerns arise regarding the potential ecological impact of gene drives.

- Reversal drives could be developed to counteract harmful gene edits.

- Monitoring and detection of gene editing in species is crucial to prevent unintended consequences.

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Link Icon 8 comments
By @thatnerd - 6 months
We're already engineering ecosystems in a thoughtless way. I find it hard to believe that messing with mosquito genetics is going to make the world significantly more risky than it already is for humanity.
By @hackeraccount - 6 months
Reading that "The astounding power of gene drives" makes the concept clear but I wonder - how could this not happen by random chance periodically? Maybe it's too infrequent to catch but doesn't it seem like occasional some species should just go extinct for seemingly no reason?

Further why wouldn't this be a positive attribute if one species could inflict it on another? I guess that's far fetched but I'm willing to admit that the logic of species interactions could very well be something that I haven't thought out.

By @K0balt - 6 months
One thing I am not understanding here is why not target the malaria parasite itself, instead of the mosquito? (Other than the obvious fact that mosquitoes are annoying) it seems like that would be the route of abundant caution with minimal consequences?
By @kwhitefoot - 6 months
That's the best explanation of CRISPR and gene drives I've seen.
By @Workaccount2 - 6 months
It's my understanding that the gene-edited mosquito trials have largely failed, since after a few generations the female mosquitos evolved to avoid the gene-edited males.
By @mensetmanusman - 6 months
We should have a govt agency tasked with destroying the couple types of mosquitoes that bother humans.
By @twodave - 6 months
Am I understanding correctly that the main impediment to weaponizing this gene drive idea is the difficulty of spreading the treatment to a broad population? How are these things applied to a live subject, anyway? I had always assumed an injection, but maybe an aerosol could be produced? Hopefully not.
By @e40 - 6 months
Too bad this article didn’t get more traction. Very interesting!!